Activated Human Eosinophils

Activated human eosinophils.

COMMENTARY Eosinophilia, activated eosinophils and human schistosomiasis

Eosinophils are proinflammatory cells that are associated with both allergic diseases and parasitic infections. In parasitic infections the eosinophil appears to be protective, but in allergic conditions eosinophil products are damaging and contribute to the tissue pathology of the disease. A particular property of eosinophils is that they can, like macrophages, exist in different states of act...

Extracellular Microvesicle Production by Human Eosinophils Activated by “Inflammatory” Stimuli

A key function of human eosinophils is to secrete cytokines, chemokines and cationic proteins, trafficking, and releasing these mediators for roles in inflammation and other immune responses. Eosinophil activation leads to secretion of pre-synthesized granule-stored mediators through different mechanisms, but the ability of eosinophils to secrete extracellular vesicles (EVs), very small vesicle...

Activated eosinophils in coeliac disease.

Neurotoxicity of human eosinophils.

Eosinophils contain a substance that is neurotoxic when injected intracerebrally or intrathecally into laboratory animals-an effect known as the "Gordon phenomenon." We found neurotoxic activity in eosinophils from three patients with eosinophilic syndromes by injecting cell preparations into rabbits and guinea pigs. These animals developed a syndrome of muscular rigidity and ataxia, progressin...